Cross-resistance patterns in ACNU-resistant glioma sublines in culture.

doi:10.3171/jns.1991.75.2.0277

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Article

Cross-resistance patterns in ACNU-resistant glioma sublines in culture.

Journal of neurosurgery - 1 Aug 1991

Saito Y, Nakada Y, Hotta T, Mikami T, Kurisu K, Yamada K, Kiya K, Kawamoto K, Uozumi T

Abstract excerpt

Three ACNU-resistant clones (R1, R3, and R12) were isolated from 9L rat glioma cells under selection pressure of ACNU in vitro. The authors have investigated the mechanisms of resistance and characteristics of these clones at the cellular level by studying cross-resistance patterns to chemical an...

Topics

Animals
Brain Neoplasms
Clone Cells
Doxorubicin
Drug Resistance
Glioma
Glutathione
Hot Temperature
Nimustine
Phenotype
Radiation Tolerance
Rats
Rats, Inbred F344
Vinblastine

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