Article
Nalidixic acid-resistant V79 cells with reduced DNA topoisomerase II activity and amplification prone phenotype.
Mutation research - 1 Oct 1992
Di Leonardo A, Maddalena A, Cavolina P
Abstract excerpt
Spontaneously nalidixic acid-resistant lines (NAr lines) were selected from a V79 Chinese hamster cell line and phenotypically characterized. NAr lines showed an increased doubling time, a higher number of spontaneous SCE, and more interestingly, decreased DNA topoisomerase II activity. These lin...
Topics
- Animals
- Antineoplastic Agents
- Cell Line
- Cell Nucleus
- Cell Survival
- Cricetinae
- Cricetulus
- DNA
- DNA Topoisomerases, Type I
- DNA Topoisomerases, Type II
- Doxorubicin
- Drug Resistance
- Etoposide
- Gene Amplification
- Mesocricetus
- Nalidixic Acid
- Nucleic Acid Hybridization
- Phenotype