Article
[Pleiotropic changes in karyotype structure of Chinese hamster fibroblast cell lint CHL V-79 RJK in relation to their acquisition of resistance to etoposide, an inducer of apoptosis].
Tsitologiia - 1 Jan 1999
Grinchuk T M, Pavlenko M A, Artsybasheva I V, Meliksetian M B, Alekseenko L L, Pugovkina N A
Abstract excerpt
Chinese hamster fibroblasts CHL V-79 RJK were subjected to multistep selection in the presence of etoposide, known as an inhibitor of topoisomerase II and inductor of apoptosis. The karyotype of cells stably resistant to etoposide was analysed at progressive stages of selection using G-type staining of metaphase chromosomes. Multiple changes in the karyotype of resistant cells were observed at an early stage of...
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