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[Cloning of cancer-related genes of Rat6 fibroblasts by using an improved differential display method].

Shi yan sheng wu xue bao - 1 Sept 2000

Chen J, Zheng J Y, Judy Y, Hsiao W L, Chen J T, Chen R Y

Abstract excerpt

The p53 gene is the most frequently mutated gene identified so far in human cancers. When a mutant p53(135)-val gene was allowed to be over-expressed in Rat6(R6) cells, a high incidence of spontaneous transformation was observed in long-term culture of this cell line(R6 # 13-8). To identify genes involved in cell transformation, parental p53 over-expressing cell, R6 # 13-8, and its spontaneous transformant T2,...

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PMID: 12549037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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