Article
[Inheritable phenotypic normalization of rodent cells transformed by simian adenovirus SA7 E1 oncogenes by singled-stranded oligonucleotides complementary to a long region of integrated oncogenes].
Genetika - 1 Aug 1995
Grineva N I, Borovkova T V, Sats N V, Kurabekova R M, Rozhitskaia O S, Solov'ev G Ia, Pantin V I
Abstract excerpt
G11 mouse cells and SH2 rat cells transformed with simian adenovirus SA7 DNA showed inheritable oncogen-specific phenotypic normalization when treated with sense and antisense oligonucleotides complementary to long RNA sequences, plus or minus strands of the integrated adenovirus oncogenes E1A and E1B. Transitory treatment of the cells with the oligonucleotides in the absence of serum was shown to cause the...
Topics
- 3T3 Cells
- Adenovirus E1 Proteins
- Adenoviruses, Simian
- Animals
- Cell Line, Transformed
- Cell Transformation, Viral
- DNA, Complementary
- Gene Expression Regulation, Viral
- Mice
- Oligonucleotides