Production of stable phenotypes from 9L rat brain tumor multicellular spheroids treated with 1,3-bis(2-chloroethyl)-1-nitrosourea.

doi:10.1002/ijc.2910520314

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Article

Production of stable phenotypes from 9L rat brain tumor multicellular spheroids treated with 1,3-bis(2-chloroethyl)-1-nitrosourea.

International journal of cancer - 30 Sept 1992

Barcellos-Hoff M H, Linfoot P A, Marton L J, Deen D F

Abstract excerpt

During chemotherapy and regrowth of brain tumors, tumor-cell heterogeneity, and possibly tumor progression, may change as a result of both the selective forces and mutagenic effects of treatment. We have isolated and characterized drug-response variants of multicellular rat 9L brain-tumor spheroi...

Topics

Animals
Brain Neoplasms
Carmustine
Drug Resistance
Phenotype
Rats
Tumor Cells, Cultured

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