Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Production of stable phenotypes from 9L rat brain tumor multicellular spheroids treated with 1,3-bis(2-chloroethyl)-1-nitrosourea.

International journal of cancer - 30 Sept 1992

Barcellos-Hoff M H, Linfoot P A, Marton L J, Deen D F

Abstract excerpt

During chemotherapy and regrowth of brain tumors, tumor-cell heterogeneity, and possibly tumor progression, may change as a result of both the selective forces and mutagenic effects of treatment. We have isolated and characterized drug-response variants of multicellular rat 9L brain-tumor spheroids exposed to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Ten colonies were isolated from spheroids disaggregated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 1399117
DOI: 10.1002/ijc.2910520314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Production of stable phenotypes from 9L rat brain tumor multicellular spheroids treated with 1,3-bis(2-chloroethyl)-1-nitrosourea.PMID 1399117Read ↗

Invasive phenotype observed in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant sublines of 9L rat glioma cells: a tumor model mimicking a recurrent malignant glioma.Semantic proximity Read ↗

Cross-resistance patterns in ACNU-resistant glioma sublines in culture.Semantic proximity Read ↗

Rapid Acquisition of Multicellular Drug Resistance After a Single Exposure of Mammary Tumor Cells to Antitumor Alkylating AgentsSemantic proximity Read ↗

lacZ transduction of 9L rat tumor cells without cloning.Semantic proximity Read ↗

Isolation of Two Cell Lines from a Human Malignant Glioma Specimen Differing in Sensitivity to Radiation and Chemotherapeutic DrugsSemantic proximity Read ↗

[Establishment of ACNU-resistant rat gliosarcoma cell lines and their characteristics].Semantic proximity Read ↗

Isolation of radiosensitive and radioresistant mutants from a medulloblastoma cell line.Semantic proximity Read ↗

Radioresistance induced in rat embryo cells by transfection with the oncogenes H-ras plus v-myc is cell cycle dependent and maximal during S and G2.Semantic proximity Read ↗

Oxygen-resistant multipotent embryonic carcinoma cell lines exhibit antimutator phenotypes.Semantic proximity Read ↗

Cytogenetic variability and kinetochore proteins. Comparison among populations derived from single-cell cultures.Semantic proximity Read ↗

Sensitization of rat glioblastoma multiforme to cisplatin in vivo following restoration of wild-type p53 function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.