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S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis

8 Jan 2007

Abstract excerpt

Prefrontal cortex (Brodmann's area 9) levels of the methyl donor S-adenosyl methionine were increased by about two-fold in schizophrenia and bipolar disorder patients, but not in unipolar depressed patients compared with nonpsychiatric subjects from the Stanley Foundation Neuropathology Consortium (Bethesda, Maryland, USA). Neither age, brain weight and pH, hemisphere, post-mortem interval, disease...

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PMID: 17259861
DOI: 10.1097/wnr.0b013e32800fefd7

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