Article
Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability.
Epigenetics - 1 Jan 2000
Costa Erminio, Dong Erbo, Grayson Dennis R, Guidotti Alessandro, Ruzicka William, Veldic Marin
Abstract excerpt
In this review, we discuss changes in the regulation of gene expression in the central nervous system (CNS) associated with DNA (cytosine-5) methylation, chromatin remodeling and post-translational covalent modifications of histones. During brain development, abnormal intrinsic or extrinsic cues may compromise epigenetic processes regulating neural stem cell proliferation and differentiation and thus directly or...
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