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Article

A Methionine-Induced Animal Model of Schizophrenia: Face and Predictive Validity

19 May 2015

Abstract excerpt

BACKGROUND: Modulating the methylation process induces broad biochemical changes, some of which may be involved in schizophrenia. Methylation is in particular central to epigenesis, which is also recognized as a factor in the etiology of schizophrenia. Because methionine administration to patients with schizophrenia has been reported to exacerbate their psychotic symptoms and because mice treated with methionine...

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PMID: 25991655
DOI: 10.1093/ijnp/pyv054

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