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Article

The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum

2 Jan 2014

Abstract excerpt

BACKGROUND: The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a therapeutic equivalent treatment of olanzapine on DNA methylation in a rat model in vivo.Genome-wide DNA methylation was assessed using a MeDIP-chip analysis. All methylated DNA immunoprecipitation (MeDIP), sample labelling, hybridization and processing were performed by Arraystar Inc...

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PMID: 24382160
DOI: 10.1186/1868-7083-6-1

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