Article
A decrease of reelin expression as a putative vulnerability factor in schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 1998
Impagnatiello F, Guidotti A R, Pesold C, Dwivedi Y, Caruncho H, Pisu M G, Uzunov D P, Smalheiser N R, Davis J M, Pandey G N, Pappas G D, Tueting P, Sharma R P, Costa E
Abstract excerpt
Postmortem prefrontal cortices (PFC) (Brodmann's areas 10 and 46), temporal cortices (Brodmann's area 22), hippocampi, caudate nuclei, and cerebella of schizophrenia patients and their matched nonpsychiatric subjects were compared for reelin (RELN) mRNA and reelin (RELN) protein content. In all of the brain areas studied, RELN and its mRNA were significantly reduced (approximately 50%) in patients with...
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