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Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosis

4 Nov 2013

Abstract excerpt

BACKGROUND: The dopamine (DA) hypothesis of schizophrenia proposes the mental illness is caused by excessive transmission of dopamine in selected brain regions. Multiple lines of evidence, including blockage of dopamine receptors by antipsychotic drugs that are used to treat schizophrenia, support the hypothesis. However, the dopamine D2 receptor (DRD2) blockade cannot explain some important aspects of the...

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PMID: 25408910
DOI: 10.1186/2049-9256-1-19

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