Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder.

doi:10.1016/j.jad.2011.03.018

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Article

Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder.

Journal of affective disorders - 1 Aug 2011

Carrard Anthony, Salzmann Annick, Malafosse Alain, Karege Félicien

Abstract excerpt

BACKGROUND: Epigenetic changes may play a role in the etiology of psychotic diseases. It has been demonstrated that the serotonin receptor, 5HTR1A, is implicated in schizophrenia (SCZ) and bipolar disorder (BPD). The aim of this study was to investigate the methylation status of a promoter region of the 5HTR1A gene in BPD and SCZ patients. METHODS: Our study included 58 BPD and 40 SCZ (DSM-IV criteria) as well as...

Topics

Adult
Bipolar Disorder
Brain
Case-Control Studies
CpG Islands
DNA Methylation
Diagnostic and Statistical Manual of Mental Disorders
Epigenesis, Genetic
Epigenomics
Female
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes

Genetic Predisposition to Disease

Humans

Leukocytes

Male

Middle Aged

Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 21453976
DOI: 10.1016/j.jad.2011.03.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21453976-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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