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Article

TPH2 polymorphisms and alcohol-related suicide.

Neuroscience letters - 18 Feb 2011

Zupanc Tomaž, Pregelj Peter, Tomori Martina, Komel Radovan, Paska Alja Videtič

Abstract excerpt

Substantial evidence from family, twin, and adoption studies corroborates implication of genetic and environmental factors, as well as their interactions, on suicidal behavior and alcoholism risk. Serotonergic disfunction seems to be involved in the pathophysiology of substance abuse, and has also an important role in suicidal behavior. Recent studies of the tryptophan hydroxylase 2 showed mild or no association...

Topics

Adult
Aged
Alcoholism
Chi-Square Distribution
Female
Gene Frequency
Genome-Wide Association Study
Genotype
Humans
Impulsive Behavior
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Risk Factors

Suicide

Tryptophan Hydroxylase

Source

Identifiers

PMID: 21182896
DOI: 10.1016/j.neulet.2010.12.030

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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