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Article

Tryptophan hydroxylase-1 gene variants associate with a group of suicidal borderline women.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2006

Zaboli Ghazal, Gizatullin Rinat, Nilsonne Asa, Wilczek Alexander, Jönsson Erik G, Ahnemark Ewa, Asberg Marie, Leopardi Rosario

Abstract excerpt

Alterations in the serotonin (5-HT) system have been related to impulsive aggression and suicidal behavior, common features of the borderline personality disorder (BPD). Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in 5-HT biosynthesis. Two isoforms are known, TPH-1 and TPH-2. TPH-1 has been correlated to various psychiatric and behavioral disorders by gene polymorphism association studies. We aimed...

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PMID: 16495936
DOI: 10.1038/sj.npp.1301046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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