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Article

Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.

Journal of virology - 1 Feb 2008

Loffredo John T, Bean Alex T, Beal Dominic R, León Enrique J, May Gemma E, Piaskowski Shari M, Furlott Jessica R, Reed Jason, Musani Solomon K, Rakasz Eva G, Friedrich Thomas C, Wilson Nancy A, Allison David B, Watkins David I

Abstract excerpt

Certain major histocompatibility complex (MHC) class I alleles are strongly associated with control of human immunodeficiency virus and simian immunodeficiency virus (SIV). CD8(+) T cells specific for epitopes restricted by these molecules may be particularly effective. Understanding how CD8(+) T cells contribute to control of viral replication should yield important insights for vaccine design. We have recently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18057253
DOI: 10.1128/JVI.02084-07
PMCID: PMC2258706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.PMID 18057253Read ↗

CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.Semantic proximity Read ↗

Mamu-B*08-positive macaques control simian immunodeficiency virus replication.Semantic proximity Read ↗

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Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication.Semantic proximity Read ↗

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