Article
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Nature immunology - 1 Feb 2006
Frahm Nicole, Kiepiela Photini, Adams Sharon, Linde Caitlyn H, Hewitt Hannah S, Sango Kaori, Feeney Margaret E, Addo Marylyn M, Lichterfeld Mathias, Lahaie Matthew P, Pae Eunice, Wurcel Alysse G, Roach Timothy, St John M Anne, Altfeld Marcus, Marincola Francesco M, Moore Corey, Mallal Simon, Carrington Mary, Heckerman David, Allen Todd M, Mullins James I, Korber Bette T, Goulder Philip J R, Walker Bruce D, Brander Christian
Abstract excerpt
Despite limited data supporting the superiority of dominant over subdominant responses, immunodominant epitopes represent the preferred vaccine candidates. To address the function of subdominant responses in human immunodeficiency virus infection, we analyzed cytotoxic T lymphocyte responses restricted by HLA-B*1503, a rare allele in a cohort infected with clade B, although common in one infected with clade C....
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