The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers.

doi:10.1128/JVI.01816-07

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Article

The major histocompatibility complex class II alleles Mamu-DRB11003 and -DRB10306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers.

Journal of virology - 1 Jan 2008

Giraldo-Vela Juan P, Rudersdorf Richard, Chung Chungwon, Qi Ying, Wallace Lyle T, Bimber Benjamin, Borchardt Gretta J, Fisk Debra L, Glidden Chrystal E, Loffredo John T, Piaskowski Shari M, Furlott Jessica R, Morales-Martinez Juan P, Wilson Nancy A, Rehrauer William M, Lifson Jeffrey D, Carrington Mary, Watkins David I

Abstract excerpt

The role of CD4(+) T cells in the control of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication is not well understood. Even though strong HIV- and SIV-specific CD4(+) T-cell responses have been detected in individuals that control viral replication, major histocompatibility complex class II (MHC-II) molecules have not been definitively linked with slow disease progression. In...

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PMID: 17989178
DOI: 10.1128/JVI.01816-07
PMCID: PMC2224575

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The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers.PMID 17989178Read ↗

Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.Semantic proximity Read ↗

Mamu-B*08-positive macaques control simian immunodeficiency virus replication.Semantic proximity Read ↗

CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.Semantic proximity Read ↗

Escape from CD8+ T Cell Responses in Mamu-B*00801+ Macaques Differentiates Progressors from Elite ControllersSemantic proximity Read ↗

Infection with "escaped" virus variants impairs control of simian immunodeficiency virus SIVmac239 replication in Mamu-B*08-positive macaques.Semantic proximity Read ↗

Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8 + T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after InfectionSemantic proximity Read ↗

Mamu-B*17+ Rhesus Macaques Vaccinated with env, vif, and nef Manifest Early Control of SIVmac239 Replication.Semantic proximity Read ↗

SIV-infected Chinese-origin rhesus macaques express specific MHC class I alleles in either elite controllers or normal progressors.Semantic proximity Read ↗

The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication.Semantic proximity Read ↗

Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication.Semantic proximity Read ↗

MHC class I alleles influence set-point viral load and survival time in simian immunodeficiency virus-infected rhesus monkeys.Semantic proximity Read ↗

Acute-phase CD4+ T cell responses targeting invariant viral regions are associated with control of live-attenuated simian immunodeficiency virusSemantic proximity Read ↗

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