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Article

Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.

Gastroenterology - 1 Jan 2007

Daly Ann K, Aithal Guruprasad P, Leathart Julian B S, Swainsbury Richard A, Dang Tarana Singh, Day Christopher P

Abstract excerpt

BACKGROUND & AIMS: Diclofenac is a widely used nonsteroidal anti-inflammatory drug and is among the most common drugs causing idiosyncratic hepatotoxicity in several recent series with up to 20% mortality in jaundiced subjects. We hypothesized that susceptibility to hepatotoxicity would be associated with genetic polymorphisms in the genes encoding the enzymes UGT2B7 and CYP2C8, which determine the formation of...

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Share to Anti-Inflammatory Agents, Non-Steroidal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

Share to Cytochrome P-450 CYP2C8

Share to Glucuronosyltransferase

Share to Membrane Transport Proteins

Share to Multidrug Resistance-Associated Protein 2

Share to Multidrug Resistance-Associated Proteins

Source

Identifiers

PMID: 17241877
DOI: 10.1053/j.gastro.2006.11.023

Genes

ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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