Article
Pharmacogenomics in drug induced liver injury.
Current drug metabolism - 1 Nov 2009
Andrade Raúl J, Agúndez José A G, Lucena M Isabel, Martínez Carmen, Cueto Raquel, García-Martín Elena
Abstract excerpt
Drug-induced liver injury (DILI) is a severe adverse effect. The majority of DILI cases are idiosyncratic and several mechanisms have been postulated to explain why some subjects develop DILI with drugs that are safe for the majority of individuals. Major mechanisms proposed for DILI are based on the production of reactive metabolites, immune-mediated hepatotoxicity, a "danger signal" hypothesis and/or...
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