Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.

doi:10.1053/j.gastro.2016.12.016

Article

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.

Gastroenterology - 1 Apr 2017

Nicoletti Paola, Aithal Guruprasad P, Bjornsson Einar S, Andrade Raul J, Sawle Ashley, Arrese Marco, Barnhart Huiman X, Bondon-Guitton Emmanuelle, Hayashi Paul H, Bessone Fernando, Carvajal Alfonso, Cascorbi Ingolf, Cirulli Elizabeth T, Chalasani Naga, Conforti Anita, Coulthard Sally A, Daly Mark J, Day Christopher P, Dillon John F, Fontana Robert J, Grove Jane I, Hallberg Pär, Hernández Nelia, Ibáñez Luisa, Kullak-Ublick Gerd A, Laitinen Tarja, Larrey Dominique, Lucena M Isabel, Maitland-van der Zee Anke H, Martin Jennifer H, Molokhia Mariam, Pirmohamed Munir, Powell Elizabeth E, Qin Shengying, Serrano Jose, Stephens Camilla, Stolz Andrew, Wadelius Mia, Watkins Paul B, Floratos Aris, Shen Yufeng, Nelson Matthew R, Urban Thomas J, Daly Ann K

Abstract excerpt

BACKGROUND & AIMS: We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors. METHODS: We performed a GWAS of 862 persons with DILI and 10,588 population-matched controls. The first set of cases was recruited before May 2009 in Europe (n = 137) and the United States (n = 274). The...

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Chromosomes, Human, Pair 2

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