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Article

Genetic susceptibility to hepatoxicity due to bosentan treatment in pulmonary hypertension.

Annals of hepatology - 1 Jan 2000

Seyfarth Hans-Jürgen, Favreau Nadine, Tennert Carsten, Ruffert Claudia, Halank Michael, Wirtz Hubert, Mössner Joachim, Rosendahl Jonas, Kovacs Peter, Wittenburg Henning

Abstract excerpt

BACKGROUND: Hepatotoxicity is a major side effect of treatment with bosentan in patients with pulmonary hypertension (PH). Bosentan is metabolized by the cytochrome CYP2C9 and inhibits the bile salt export pump, which is encoded by ABCB11. This suggests that genetic variants of CYP2C9 and/or ABCB11 may predispose patients to bosentan-induced liver injury. MATERIAL AND METHODS: PH patients with (n = 23) or without...

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Share to Alanine Transaminase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aspartate Aminotransferases

Share to ATP Binding Cassette Transporter, Subfamily B, Member 11

Share to Chemical and Drug Induced Liver Injury

Share to Cytochrome P-450 CYP2C9

Share to Hypertension, Pulmonary

Share to Sulfonamides

Source

Identifiers

PMID: 25332267

Genes

ABCB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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