Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of UGT2B72 and CYP2C84 polymorphisms on diclofenac metabolism.

Toxicology letters - 1 Mar 2018

Lazarska Katarzyna E, Dekker Stefan J, Vermeulen Nico P E, Commandeur Jan N M

Abstract excerpt

The use of diclofenac is associated with rare but severe drug-induced liver injury (DILI) in a very small number of patients. The factors which predispose susceptible patients to hepatotoxicity of diclofenac are still incompletely understood. Formation of protein-reactive metabolites by UDP-glucuronosyl transferases and cytochromes P450 is commonly considered to play an important role, as indicated by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C8

Share to Glucuronides

Share to Glucuronosyltransferase

Share to Hydroxylation

Share to Oxidation-Reduction

Share to Sf9 Cells

Source

Identifiers

PMID: 29203276
DOI: 10.1016/j.toxlet.2017.11.038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism.PMID 29203276Read ↗

Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.Semantic proximity Read ↗

Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis.Semantic proximity Read ↗

The role of CYP2C9 genotype in the metabolism of diclofenac in vivo and in vitro.Semantic proximity Read ↗

CYP2C9 genotypes and diclofenac metabolism in Spanish healthy volunteers.Semantic proximity Read ↗

Relationship between CYP2C8 genotypes and diclofenac 5-hydroxylation in healthy Spanish volunteers.Semantic proximity Read ↗

Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans.Semantic proximity Read ↗

How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity.Semantic proximity Read ↗

Analysis of diclofenac and its metabolites by high-performance liquid chromatography: relevance of CYP2C9 genotypes in diclofenac urinary metabolic ratios.Semantic proximity Read ↗

Effects of CYP2C9*3 and CYP2C9*13 on Diclofenac Metabolism and Inhibition-based Drug-Drug Interactions.Semantic proximity Read ↗

Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen.Semantic proximity Read ↗

Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity.Semantic proximity Read ↗

Reproducibility over time of the urinary diclofenac/4'-OH diclofenac ratio among different CYP2C9 genotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.