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Article

The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury.

Expert opinion on drug metabolism & toxicology - 1 Mar 2012

Amacher David E

Abstract excerpt

INTRODUCTION: Idiosyncratic drug-induced liver injury (DILI) is a rare, serious and sometimes fatal condition that lacks an effective clinical countermeasure. Polymorphisms of bioactivation/toxification pathways via the Phase I drug-metabolizing enzymes, Phase II detoxification reactions and Phase III excretion/transport, together with immunological factors, are predisposing factors for some DILI. AREAS COVERED:...

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Identifiers

PMID: 22288564
DOI: 10.1517/17425255.2012.658041

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