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Article

CYP2C9 genotypes and diclofenac metabolism in Spanish healthy volunteers.

European journal of clinical pharmacology - 1 Jul 2003

Dorado Pedro, Berecz Roland, Norberto Maria-Jesús, Yasar Umit, Dahl Marja-Liisa, LLerena Adrián

Abstract excerpt

OBJECTIVE: This study analyzed the frequency of CYP2C9 variant alleles and evaluated the impact of CYP2C9 genotype on diclofenac metabolism in a Spanish population. METHODS: Diclofenac hydroxylation capacity was studied in a population of 102 healthy volunteers. After a single oral dose of 50 mg diclofenac the 0- to 8-h urinary concentrations of diclofenac and its main metabolites, 4'-hydroxy (OH), 3'-OH and 5-OH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aryl Hydrocarbon Hydroxylases

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Share to Cytochrome P-450 CYP2C9

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Share to Polymorphism, Genetic

Source

Identifiers

PMID: 12734606
DOI: 10.1007/s00228-003-0588-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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