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Article

How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity.

Arhiv za higijenu rada i toksikologiju - 1 Mar 2016

Krasniqi Valon, Dimovski Aleksandar, Domjanović Iva Klarica, Bilić Ivan, Božina Nada

Abstract excerpt

Interindividual variability in drug metabolism is an important cause of adverse drug reactions and variability in drug efficiency. Polymorphisms of cytochrome P450 (CYPs) genes have a significant effect on drug metabolism and toxicity. This review brings an update about how genetic polymorphisms of CYP2C8 and CYP2C9 enzymes affect the disposition and clinical outcomes of ibuprofen and diclofenac, two of the most...

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Share to Anti-Inflammatory Agents, Non-Steroidal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27092633
DOI: 10.1515/aiht-2016-67-2754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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