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Article

Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration.

Ophthalmology - 1 Jun 2007

Scott William K, Schmidt Silke, Hauser Michael A, Gallins Paul, Schnetz-Boutaud Nathalie, Spencer Kylee L, Gilbert John R, Agarwal Anita, Postel Eric A, Haines Jonathan L, Pericak-Vance Margaret A

Abstract excerpt

OBJECTIVE: To examine the potential gene-environment interaction between cigarette smoking and the complement factor H (CFH) T1277C polymorphism, 2 strong risk factors for age-related macular degeneration (AMD). DESIGN: Retrospective case-control study. PARTICIPANTS: A university clinic-based sample of 599 people with AMD and 242 controls. METHODS: Standard criteria were used to rate disease severity (grades 1-5)...

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Source

Identifiers

PMID: 17241667
DOI: 10.1016/j.ophtha.2006.08.054

Genes

CFH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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