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Article

Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy.

Investigative ophthalmology & visual science - 1 Dec 2010

Nakanishi Hideo, Yamashiro Kenji, Yamada Ryo, Gotoh Norimoto, Hayashi Hisako, Nakata Isao, Saito Masaaki, Iida Tomohiro, Oishi Akio, Kurimoto Yasuo, Matsuo Keitaro, Tajima Kazuo, Matsuda Fumihiko, Yoshimura Nagahisa

Abstract excerpt

PURPOSE: To investigate whether the major genetic and environmental risk factors of age-related macular degeneration (AMD)-CFH Y402H and LOC387715 A69S and cigarette smoking-are also associated with polypoidal choroidal vasculopathy (PCV) and whether the associations of CFH Y402H and LOC387715 A69S with PCV are modified by smoking. METHODS: Three hundred seventy-five Japanese patients with PCV and 847 Japanese...

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Source

Identifiers

PMID: 20688737
DOI: 10.1167/iovs.09-4948

Genes

CFH
HTRA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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