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Article

Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.

PLoS medicine - 1 Dec 2007

Hughes Anne E, Orr Nick, Patterson Chris, Esfandiary Hossein, Hogg Ruth, McConnell Vivienne, Silvestri Giuliana, Chakravarthy Usha

Abstract excerpt

BACKGROUND: Age-related macular degeneration (AMD) is the major cause of blindness in the elderly. Those with the neovascular end-stage of disease have irreversible loss of central vision. AMD is a complex disorder in which genetic and environmental factors play a role. Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smoking also contributes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18162041
DOI: 10.1371/journal.pmed.0040355
PMCID: PMC2222948

Genes

CFH
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.PMID 18162041Read ↗

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