Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration.

Investigative ophthalmology & visual science - 1 Sept 2007

Spencer Kylee L, Hauser Michael A, Olson Lana M, Schnetz-Boutaud Nathalie, Scott William K, Schmidt Silke, Gallins Paul, Agarwal Anita, Postel Eric A, Pericak-Vance Margaret A, Haines Jonathan L

Abstract excerpt

PURPOSE: Age-related macular degeneration (AMD) is a devastating disorder that adversely affects the quality of life of nearly 2 million Americans who have advanced forms of the disease. Besides the well-known risk imparted by carrying the Y402H variant in the complement factor H (CFH) gene on chromosome 1, recent evidence of the existence of protective haplotypes spanning CFH has been reported. METHODS: The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement Factor H
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Haplotypes

Share to Likelihood Functions

Share to Macular Degeneration

Share to Risk Factors

Share to Smoking

Source

Identifiers

PMID: 17724217
DOI: 10.1167/iovs.06-1427

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration.PMID 17724217Read ↗

Complement factor H variant increases the risk of age-related macular degeneration.Semantic proximity Read ↗

A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration.Semantic proximity Read ↗

Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration.Semantic proximity Read ↗

A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration.Semantic proximity Read ↗

Almost total protection from age-related macular degeneration by haplotypes of the Regulators of Complement Activation.Semantic proximity Read ↗

Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular DegenerationSemantic proximity Read ↗

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.Semantic proximity Read ↗

Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.Semantic proximity Read ↗

Complement factor H polymorphism in age-related macular degeneration.Semantic proximity Read ↗

Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.Semantic proximity Read ↗

Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†.Semantic proximity Read ↗

A rare variant in CFH directly links age-related macular degeneration with rare glomerular nephropathies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.