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Article

Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular Degeneration

18 Jul 2006

Abstract excerpt

CONTEXT: The evidence that inflammation is an important pathway in age-related macular degeneration (AMD) is growing. Recent case-control studies demonstrated an association between the complement factor H (CFH) gene, a regulator of complement, and AMD. OBJECTIVES: To assess the associations between the CFH gene and AMD in the general population and to investigate the modifying effect of smoking, serum...

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PMID: 16849663
DOI: 10.1001/jama.296.3.301

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