Article
Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype.
International journal of epidemiology - 1 Feb 2012
Sofat Reecha, Casas Juan P, Webster Andrew R, Bird Alan C, Mann Samantha S, Yates John R W, Moore Anthony T, Sepp Tiina, Cipriani Valentina, Bunce Catey, Khan Jane C, Shahid Humma, Swaroop Anand, Abecasis Gonçalo, Branham Kari E H, Zareparsi Sepideh, Bergen Arthur A, Klaver Caroline C W, Baas Dominique C, Zhang Kang, Chen Yuhong, Gibbs Daniel, Weber Bernhard H F, Keilhauer Claudia N, Fritsche Lars G, Lotery Andrew, Cree Angela J, Griffiths Helen L, Bhattacharya Shomi S, Chen Li L, Jenkins Sharon A, Peto Tunde, Lathrop Mark, Leveillard Thierry, Gorin Michael B, Weeks Daniel E, Ortube Maria Carolina, Ferrell Robert E, Jakobsdottir Johanna, Conley Yvette P, Rahu Mati, Seland Johan H, Soubrane Gisele, Topouzis Fotis, Vioque Jesus, Tomazzoli Laura, Young Ian, Whittaker John, Chakravarthy Usha, de Jong Paulus T V M, Smeeth Liam, Fletcher Astrid, Hingorani Aroon D
Abstract excerpt
BACKGROUND: Variation in the complement factor H gene (CFH) is associated with risk of late age-related macular degeneration (AMD). Previous studies have been case-control studies in populations of European ancestry with little differentiation in AMD subtype, and insufficient power to confirm or refute effect modification by smoking. METHODS: To precisely quantify the association of the single nucleotide...
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