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Article

Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo.

Nucleic acids research - 1 Dec 2010

Sharbeen George, Cook Adam J L, Lau K K Edwin, Raftery Joanna, Yee Christine W Y, Jolly Christopher J

Abstract excerpt

Activation-induced cytidine deaminase (AID) protein initiates Ig gene mutation by deaminating cytosines, converting them into uracils. Excision of AID-induced uracils by uracil-N-glycosylase is responsible for most transversion mutations at G:C base pairs. On the other hand, processing of AID-ind...

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Identifiers

PMID: 20705648
DOI: 10.1093/nar/gkq682
PMCID: PMC3001060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20705648-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo.PMID 20705648Read ↗

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