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Article

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine.

Nucleic acids research - 14 Jan 2026

Bilardi Rebecca A, Flensburg Christoffer, Xu Zhen, Derrick Emily B, Kueh Andrew, Majewski Ian J

Abstract excerpt

5-Methylcytosine (5mC) is a common source of somatic mutations. Deamination of 5mC to thymine generates a G/T mismatch, which occurs spontaneously and must be repaired prior to DNA replication to avoid mutation. We generated genetically engineered mice and cell lines to define DNA repair pathways that protect against 5mC deamination. We observed a low background mutation rate in mouse bone marrow or colon,...

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Identifiers

PMID: 41556338
DOI: 10.1093/nar/gkaf1493
PMCID: PMC12817082

Genes

TG

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Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine.PMID 41556338Read ↗

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