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Article

DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse

26 Dec 2006

Abstract excerpt

Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2-MSH6 proteins, together with DNA polymerase eta (pol eta). However, residual A/T mutagenesis is still observed upon inactivation in the mouse of each of these factors, suggesting that the panel of activities involved might be...

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PMID: 17190840
DOI: 10.1084/jem.20062131

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DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mousePMID 17190840Read ↗

Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouseSemantic proximity Read ↗

Somatic hypermutation at A/T-rich oligonucleotide substrates shows different strand polarities in Ung-deficient or -proficient backgrounds.Semantic proximity Read ↗

DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions.Semantic proximity Read ↗

Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.Semantic proximity Read ↗

Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification.Semantic proximity Read ↗

Hijacked DNA repair proteins and unchained DNA polymerases.Semantic proximity Read ↗

Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias.Semantic proximity Read ↗

Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.Semantic proximity Read ↗

Altered spectra of hypermutation in DNA repair-deficient mice.Semantic proximity Read ↗

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosineSemantic proximity Read ↗

MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites.Semantic proximity Read ↗

DNA polymerase eta is a limiting factor for A:T mutations in Ig genes and contributes to antibody affinity maturation.Semantic proximity Read ↗

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