Article
Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.
Virology - 25 May 2007
Gorry Paul R, Dunfee Rebecca L, Mefford Megan E, Kunstman Kevin, Morgan Tom, Moore John P, Mascola John R, Agopian Kristin, Holm Geoffrey H, Mehle Andrew, Taylor Joann, Farzan Michael, Wang Hui, Ellery Philip, Willey Samantha J, Clapham Paul R, Wolinsky Steven M, Crowe Suzanne M, Gabuzda Dana
Abstract excerpt
Heterozygosity for the CCR5 Delta32 allele is associated with delayed progression to AIDS in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an unusual HIV-1 isolate from the blood of an asymptomatic individual who was heterozygous for the CCR5 Delta32 allele and had reduced levels of CCR5 expression. The primary virus used CCR5, CXCR4, and an unusually broad range of alternative...
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