Article
The evolutionary history of the CCR5-Delta32 HIV-resistance mutation.
Microbes and infection - 1 Feb 2005
Galvani Alison P, Novembre John
Abstract excerpt
The CCR5 chemokine receptor is exploited by HIV-1 to gain entry into CD4+ T cells. A deletion mutation (Delta32) confers resistance against HIV by obliterating the expression of the receptor on the cell surface. Intriguingly, this allele is young in evolutionary time, yet it has reached relatively high frequencies in Europe. These properties indicate that the mutation has been under intense positive selection....
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