Article
Restricted variable residues in the C-terminal segment of HIV-1 V3 loop regulate the molecular anatomy of CCR5 utilization.
Journal of molecular biology - 22 Jul 2005
Hu Qinxue, Napier Kelby B, Trent John O, Wang Zixuan, Taylor Stephen, Griffin George E, Peiper Stephen C, Shattock Robin J
Abstract excerpt
The V3 loop of the HIV-1 envelope glycoprotein (Env) is the major determinant for coreceptor utilization, but the structural basis for this specificity remains to be defined. By characterizing a set of naturally occurring R5 Env variants, we demonstrate that Asp324 in the conserved IIGDIR motif of the V3 loop (CTRPN(300)NNTRKSIHIGP(311)GRAFYTTGEIIGD(324)IRQAHC) C-terminal segment regulates the molecular anatomy...
Topics
- Amino Acid Sequence
- Asparagine
- Aspartic Acid
- CD4-Positive T-Lymphocytes
- Chemokine CCL5
- Gene Products, env
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans