Article
Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Delta 32 allele.
Lancet (London, England) - 25 May 2002
Gorry Paul R, Zhang Chengsheng, Wu Sam, Kunstman Kevin, Trachtenberg Elizabeth, Phair John, Wolinsky Steven, Gabuzda Dana
Abstract excerpt
Entry of HIV-1 into a cell happens only after viral envelope glycoproteins have bound to CD4 and a chemokine receptor. Generally, macrophage-tropic strains use CCR5, and T cell-line-tropic strains use CXCR4 as coreceptors for virus entry. Dual-tropic viruses can use both CCR5 and CXCR4. About 1% of white people are homozygous for a non-functional CCR5 allele, containing a 32 base pair deletion (CCR5 Delta 32). We...
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