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Article

Shared epitopes among HLA class II alleles: gene conversion, common ancestry and balancing selection.

Immunology today - 1 Nov 1991

Erlich H A, Gyllensten U B

Abstract excerpt

The extent and pattern of HLA class II sequence polymorphism raise a variety of evolutionary questions, notably those concerning the genetic mechanisms for generating diversity, the rate of change and the nature of the selection pressure maintaining this variation. Phylogenetic analysis of primate MHC class II sequences suggests that the allelic lineages are ancient, having diverged long before separation of the...

Topics

Alleles
Amino Acid Sequence
Animals
Biological Evolution
Epitopes
Gene Conversion
HLA-DR Antigens
Molecular Sequence Data
Polymorphism, Genetic
Primates
Selection, Genetic

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Identifiers

PMID: 1723876
DOI: 10.1016/0167-5699(91)90143-H

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1723876-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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