Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

doi:10.1534/genetics.106.057034

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

Genetics - 1 Jul 2006

Shiina Takashi, Ota Masao, Shimizu Sayoko, Katsuyama Yoshihiko, Hashimoto Nami, Takasu Miwa, Anzai Tatsuya, Kulski Jerzy K, Kikkawa Eri, Naruse Taeko, Kimura Natsuki, Yanagiya Kazuyo, Watanabe Atsushi, Hosomichi Kazuyoshi, Kohara Sakae, Iwamoto Chie, Umehara Yumi, Meyer Alice, Wanner Valérie, Sano Kazumi, Macquin Cécile, Ikeo Kazuho, Tokunaga Katsushi, Gojobori Takashi, Inoko Hidetoshi, Bahram Seiamak

Abstract excerpt

A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an analysis of single nucleotide variations (SNV) across this entire segment. This diversity was not evenly distributed. It was rather concentrated within two gene-rich clusters. These were each centered, but importantly not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA

Share to Evolution, Molecular

Share to Genes, MHC Class I

Share to Macaca mulatta

Share to Models, Genetic

Share to Pan troglodytes

Share to Primates

Source

Open in PubMed Open full text

Identifiers

PMID: 16702430
DOI: 10.1534/genetics.106.057034
PMCID: PMC1526686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.PMID 16702430Read ↗

Advances in the Evolutionary Understanding of MHC Polymorphism.Semantic proximity Read ↗

Trans-species polymorphism in humans and the great apes is generally maintained by balancing selection that modulates the host immune responseSemantic proximity Read ↗

Ancient Trans-Species Polymorphism at the Major Histocompatibility Complex in PrimatesSemantic proximity Read ↗

Pathogen-driven selection and worldwide HLA class I diversity.Semantic proximity Read ↗

Genetic divergence of the rhesus macaque major histocompatibility complex.Semantic proximity Read ↗

SNP profile within the human major histocompatibility complex reveals an extreme and interrupted level of nucleotide diversity.Semantic proximity Read ↗

Evolution of MHC class I genes in higher primates.Semantic proximity Read ↗

The major histocompatibility complex and human evolution.Semantic proximity Read ↗

Comparative genetics of the major histocompatibility complex in humans and nonhuman primates.Semantic proximity Read ↗

Human MHC architecture and evolution: implications for disease association studies.Semantic proximity Read ↗

The evolution of allelic diversity at the primate major histocompatibility complex class II loci.Semantic proximity Read ↗

Ancient haplotypes of the HLA Class II region.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.