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Article

A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells

29 Mar 2018

Abstract excerpt

Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosstalk between these branches. Of note, a shift from IGF to Wnt signaling has been observed during aging of satellite cells. Biological regulatory networks necessary to...

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PMID: 29596489
DOI: 10.1371/journal.pone.0195126

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