Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mathematical modelling suggests a differential impact of β-transducin repeat-containing protein paralogues on Wnt/β-catenin signalling dynamics.

The FEBS journal - 1 Mar 2015

Benary Uwe, Kofahl Bente, Hecht Andreas, Wolf Jana

Abstract excerpt

The Wnt/β-catenin signalling pathway is involved in the regulation of a multitude of cellular processes by controlling the concentration of the transcriptional regulator β-catenin. Proteasomal degradation of β-catenin is mediated by two β-transducin repeat-containing protein paralogues, homologou...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Feedback, Physiological
Share to Genes, APC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Theoretical

Share to Proteasome Endopeptidase Complex

Share to TCF Transcription Factors

Share to Transducin

Share to Wnt Proteins

Source

Identifiers

PMID: 25601154
DOI: 10.1111/febs.13204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25601154-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mathematical modelling suggests a differential impact of β-transducin repeat-containing protein paralogues on Wnt/β-catenin signalling dynamics.PMID 25601154Read ↗

A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways.Semantic proximity Read ↗

Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes.Semantic proximity Read ↗

Construction and Experimental Validation of a Petri net Model of Wnt/β-catenin SignalingSemantic proximity Read ↗

A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cellsSemantic proximity Read ↗

Elucidating the interactions between the adhesive and transcriptional functions of beta-catenin in normal and cancerous cells.Semantic proximity Read ↗

A Theoretical Model of the Wnt Signaling Pathway in the Epithelial Mesenchymal Transition.Semantic proximity Read ↗

Wnt target gene activation requires β-catenin separation into biomolecular condensates.Semantic proximity Read ↗

A mode of regulation of beta-catenin signaling activity in Xenopus embryos independent of its levels.Semantic proximity Read ↗

Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model.Semantic proximity Read ↗

β-catenin-mediated activation of Wnt target genes utilizes a biomolecular condensate-dependent mechanismSemantic proximity Read ↗

The impact of the regulatory design on the response of epidermal growth factor receptor-mediated signal transduction towards oncogenic mutations.Semantic proximity Read ↗

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.