Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.

The Journal of biological chemistry - 13 Jan 2006

Lin Yun-Wei, Yang Jia-Ling

Abstract excerpt

The dual-specificity MAPK phosphatase MKP-1/CL100/DUSP1 is an inducible nuclear protein controlled by p44/42 MAPK (ERK1/2) in a negative feedback mechanism to inhibit kinase activity. Here, we report on the molecular basis for a novel positive feedback mechanism to sustain ERK activation by triggering MKP-1 proteolysis. Active ERK2 docking to the DEF motif (FXFP, residues 339-342) of N-terminally truncated MKP-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Signal-Regulated MAP Kinases
Share to Feedback, Physiological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immediate-Early Proteins

Share to Mitogen-Activated Protein Kinase 1

Share to Phosphoprotein Phosphatases

Share to Protein Phosphatase 1

Share to S-Phase Kinase-Associated Proteins

Share to SKP Cullin F-Box Protein Ligases

Source

Identifiers

PMID: 16286470
DOI: 10.1074/jbc.M508720200

Genes

DUSP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.PMID 16286470Read ↗

Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases.Semantic proximity Read ↗

The MEK/ERK cascade: from signaling specificity to diverse functions.Semantic proximity Read ↗

Regulation of the Activity of the Dual Leucine Zipper Kinase by Distinct MechanismsSemantic proximity Read ↗

Conserved cross-interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual-specificity phosphatase MKP3.Semantic proximity Read ↗

Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition.Semantic proximity Read ↗

Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism.Semantic proximity Read ↗

Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.Semantic proximity Read ↗

Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.Semantic proximity Read ↗

A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways.Semantic proximity Read ↗

SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cellsSemantic proximity Read ↗

Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5.Semantic proximity Read ↗

Role and regulation of MKP-1 in airway inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.