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Article

Crosstalk between PI3K/Akt and Wnt/β-catenin pathways promote colorectal cancer progression regardless of mutational status.

Cancer biology & therapy - 31 Dec 2022

Fleming-de-Moraes Cassio Dejair, Rocha Murilo Ramos, Tessmann Josiane Weber, de Araujo Wallace Martins, Morgado-Diaz Jose Andres

Abstract excerpt

The PI3K/Akt and Wnt/β-catenin pathways play an important role in the acquisition of the malignant phenotype in cancer. However, there are few data regarding the role of the interplay between both pathways in colorectal cancer (CRC) progression. The mutational status and the clinicopathological characteristics of PI3K/Akt and Wnt/β-catenin pathways were accessed by bioinformatic analysis whereas that the impact...

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Identifiers

PMID: 35944058
DOI: 10.1080/15384047.2022.2108690
PMCID: PMC9367664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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