Article

Computational Modeling and Analysis of the TGF-β-induced ERK and SMAD Pathways

2024-11-09

Abstract excerpt

TGF-β, an important cytokine that plays a key role in many diseases regulates a wide array of cellular and physiologic processes via several TGF-β-driven signaling cascades, including the SMAD and non-SMAD-driven pathways. However, the detailed mechanisms by which TGF-β induces such diverse responses remain poorly understood. In particular, compared to the SMAD-dependent pathway, SMAD-independent pathways such as...

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Literature Corpus work: 5a3a27dd-d2fc-582b-853a-7e421a56b7c8
DOI: 10.1101/2024.11.07.622480

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