Article
MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression.
eLife - 17 Sept 2020
Aikin Timothy J, Peterson Amy F, Pokrass Michael J, Clark Helen R, Regot Sergi
Abstract excerpt
A large fraction of human cancers contain genetic alterations within the Mitogen Activated Protein Kinase (MAPK) signaling network that promote unpredictable phenotypes. Previous studies have shown that the temporal patterns of MAPK activity (i.e. signaling dynamics) differentially regulate cell behavior. However, the role of signaling dynamics in mediating the effects of cancer driving mutations has not been...
Topics
- ADAM17 Protein
- Cell Line, Tumor
- ErbB Receptors
- Gene Expression Regulation, Neoplastic
- Humans
- MAP Kinase Signaling System
- Mitogen-Activated Protein Kinases
- Mutation
- Neoplasms
- Oncogenes