Article
Detailed genetic characterization of the interleukin-23 receptor in psoriasis.
Genes and immunity - 1 Sept 2008
Garcia V E, Chang M, Brandon R, Li Y, Matsunami N, Callis-Duffin K P, Civello D, Rowland C M, Bui N, Catanese J J, Krueger G G, Leppert M F, Begovich A B, Schrodi S J
Abstract excerpt
Using a multi-tiered, case-control association design, scanning 25 215 gene-centric SNPs, we previously identified two psoriasis susceptibility genes: IL12B and IL23R. These results have recently been confirmed. To better characterize the IL23R psoriasis-association, we used a fine mapping strategy to identify 59 additional IL23R-linked SNPs, which were genotyped in our three independent, white North American...
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