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Article

IL12B, IL23A, IL23R and HLA-C*06 genetic variants in psoriasis susceptibility and response to treatment.

Human immunology - 1 Apr 2018

Bojko Adriana, Ostasz Roksana, Białecka Monika, Klimowicz Adam, Malinowski Damian, Budawski Robert, Bojko Piotr, Droździk Marek, Kurzawski Mateusz

Abstract excerpt

The role of interleukin-23 is crucial in the pathogenesis of psoriasis, and IL23A, IL12B and IL23R genetic variants have been associated with the disease in genome-wide association studies. In the current paper we have conducted a confirmation study of the abovementioned genetic factors in a case-control analysis of 507 psoriatic patients and 396 controls from a Polish population, and subsequently analyzed the...

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PMID: 29454820
DOI: 10.1016/j.humimm.2018.02.003

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