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Article

Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.

Human molecular genetics - 1 May 2013

Johnston Andrew, Xing Xianying, Swindell William R, Kochkodan James, Riblett Marybeth, Nair Rajan P, Stuart Philip E, Ding Jun, Voorhees John J, Elder James T, Gudjonsson Johann E

Abstract excerpt

The IL12B gene encodes the common p40 subunit of IL-12 and IL-23, cytokines with key roles in Th1 and Th17 biology, respectively, and genetic variation in this region significantly influences risk of psoriasis. Here, we demonstrate that a psoriasis-associated risk haplotype at the IL12B locus lea...

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Share to Chemokine CXCL10
Share to Interleukin-12 Subunit p40
Share to Interleukin-17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Keratinocytes

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Source

Open in PubMed Open full text

Identifiers

PMID: 23376980
DOI: 10.1093/hmg/ddt034
PMCID: PMC3613166

Genes

CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23376980-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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